<p><em>VKORC1</em> variants as significant predictors of warfarin dose in Emiratis</p>
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چکیده
منابع مشابه
Frequency of two VKORC1 gene variants and its correlation with warfarin maintenance dose
Warfarin is a commonly-prescribed anticoagulant used to treat and prevent thromboembolic events. The requirement for varying doses of warfarin depends on genetic and environmental components. In this study, the frequency of two single-nucleotide polymorphic variants of the vitamin K epoxide reductase complex subunit 1 (VKORC1) gene (1173 C>T (rs9934438) and 3730 G>A (rs7294)) and its correlatio...
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Effects of fixed low-dose warfarin, aspirin-warfarin combination therapy, and dose-adjusted warfarin on thrombogenesis in chronic atrial fibrillation.
BACKGROUND AND PURPOSE Recent clinical trials have established that adjusted-dose warfarin (international normalized ratio [INR] 2.0 to 3.0) is highly effective in the reduction of ischemic stroke in patients with nonvalvular atrial fibrillation (AF). We hypothesized that the introduction of fixed low-dose warfarin alone or in combination with aspirin (300 mg) could normalize hemostatic markers...
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BACKGROUND VKORC1 and CYP2C9 are important contributors to warfarin dose variability, but explain less variability for individuals of African descent than for those of European or Asian descent. We aimed to identify additional variants contributing to warfarin dose requirements in African Americans. METHODS We did a genome-wide association study of discovery and replication cohorts. Samples f...
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ژورنال
عنوان ژورنال: Pharmacogenomics and Personalized Medicine
سال: 2019
ISSN: 1178-7066
DOI: 10.2147/pgpm.s187350